Ryzhenkov V E, Remezova O V, Triufanov V F, Vasil'eva L E
Eksp Klin Farmakol. 1992 Sep-Oct;55(5):39-41.
Experiments on rats, guinea pigs and rabbits with hyperlipidemia induced by high-cholesterol diet have revealed that the specific antihypoxic drug oliphen has hypolipidemic effect which is least pronounced in oral GABA. Oliphen causes a significant increase in alpha-cholesterol (antiatherogenic lipoprotein cholesterol) decreased by hyperlipidemia. It is suggested that oliphen improves hepatic receptor-dependent uptake and atherogenic lipoprotein degradation.
对用高胆固醇饮食诱导高脂血症的大鼠、豚鼠和兔子进行的实验表明,特定的抗缺氧药物奥利芬具有降血脂作用,在口服γ-氨基丁酸时这种作用最不明显。奥利芬能使因高脂血症而降低的α-胆固醇(抗动脉粥样硬化脂蛋白胆固醇)显著增加。有人认为,奥利芬可改善肝脏受体依赖性摄取和动脉粥样硬化脂蛋白降解。