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[水溶性胆固醇和胆汁酸肠吸附剂在实验中的降血脂作用]

[The hypolipidemic action of water-soluble enterosorbents of cholesterol and bile acids in an experiment].

作者信息

Chistiakova A M, Frolova Iu V, Triufanov V F, Vasil'eva L E, Lozovskiĭ V T, Ryzhenkov V E

出版信息

Eksp Klin Farmakol. 1992 Sep-Oct;55(5):41-4.

PMID:1305451
Abstract

Experiments on rats, guinea pigs and rabbits with experimental dyslipoproteinemia have revealed that the new water-soluble high-molecular weight polymers containing digitonin (ED) or a quaternary nitrogen atom (EA) have a more marked hypolipidemic action than cholestyramine and normalize lipoprotein metabolism. The digitonin-containing enterosorbent has been shown to decrease the absorption of 4-14C-cholesterol, while the nitrogen-containing enterosorbent diminishes the absorption of 3H-cholic acid.

摘要

对患有实验性血脂蛋白异常血症的大鼠、豚鼠和兔子进行的实验表明,含有洋地黄皂苷(ED)或季氮原子(EA)的新型水溶性高分子聚合物比消胆胺具有更显著的降血脂作用,并能使脂蛋白代谢正常化。已证明含洋地黄皂苷的肠吸附剂可降低4-14C-胆固醇的吸收,而含氮肠吸附剂可减少3H-胆酸的吸收。

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