Lesot H, Begue-Kirn C, Smith A J, Fausser J L, Ruch J V
Institut de Biologie Médicale, INSERM CJF 88-08, Faculté de Médecine, Strasbourg.
C R Seances Soc Biol Fil. 1992;186(5):485-500.
The terminal differentiation of odontoblasts requires the integrity of the cytoskeleton and is controlled by cell-matrix interactions. These interactions implicate both matrix molecules and matrix-associated growth factors. On the one hand, predentin-dentin constituents were found to initiate odontoblast differentiation and to allow the maintenance of this state; TGF-beta or related molecules are implicated. Fibronectin on the other hand can induce the differentiation of second generation odontoblasts and interacts with three high molecular weight proteins present in membrane prepared from dental mesenchymal cells. One of these proteins (165 kDa) was localized on the surface of odontoblasts and is involved in the organization of microfilaments. Two main axes of research will have to be developed in the future in order to understand how matrix molecules and growth factors interactions can be modulated in time and space by epithelial and mesenchymal cells, and how such modulations can affect the phenotype of these cells.
成牙本质细胞的终末分化需要细胞骨架的完整性，并受细胞与基质相互作用的控制。这些相互作用涉及基质分子和与基质相关的生长因子。一方面，前期牙本质-牙本质成分被发现可启动成牙本质细胞分化并维持这种状态；转化生长因子-β或相关分子与此有关。另一方面，纤连蛋白可诱导第二代成牙本质细胞的分化，并与存在于牙间充质细胞膜中的三种高分子量蛋白质相互作用。其中一种蛋白质（165 kDa）定位于成牙本质细胞表面，并参与微丝的组织。为了理解上皮细胞和间充质细胞如何在时间和空间上调节基质分子与生长因子的相互作用，以及这种调节如何影响这些细胞的表型，未来将不得不开展两条主要的研究途径。
