Taguchi A
Department of Neurosurgery, Kurume University School of Medicine, Japan.
Kurume Med J. 1992;39(4):267-78. doi: 10.2739/kurumemedj.39.267.
The clinical significance of Thallium-201 single-photon emission computerized tomography (Tl-201 SPECT) in the evaluation of viability of gliomas was studied comparatively with histological examination of tumor tissue using Ki-67 and proliferative cell nuclear antigen (PCNA) monoclonal antibody. The relationship between radionuclide uptake of Tl-201 in tumor specimens and labeling indices of special staining using Ki-67 and PCNA monoclonal antibodies were also studied. The population studied consisted of 17 patients with glioma. Tl-201 indices obtained from early and delayed images and its washout rates were used for quantitative analysis of Tl-201 SPECT findings. Tl-201 indices showed high values according to the histological malignancy of gliomas. Radionuclide uptake of Tl-201 in the tumor specimens were also high in those with high labeling indices of Ki-67 and PCNA. The lesions with marked Tl-201 uptake on early and delayed images had numerous Ki-67 and PCNA positive-stained cells. The lesion with low Tl-201 washout rate therefore reflected well the more viable lesion in the tumor tissue. It is concluded that the viability of gliomas including anaplastic changes and response of gliomas to the treatment can be detected by serial study with Tl-201 SPECT.
采用Ki-67和增殖细胞核抗原（PCNA）单克隆抗体对肿瘤组织进行组织学检查，比较研究了铊-201单光子发射计算机断层扫描（Tl-201 SPECT）在评估神经胶质瘤生存能力方面的临床意义。还研究了肿瘤标本中Tl-201的放射性核素摄取与使用Ki-67和PCNA单克隆抗体进行特殊染色的标记指数之间的关系。研究对象为17例神经胶质瘤患者。从早期和延迟图像获得的Tl-201指数及其洗脱率用于对Tl-201 SPECT检查结果进行定量分析。根据神经胶质瘤的组织学恶性程度，Tl-201指数显示出较高的值。在Ki-67和PCNA标记指数较高的肿瘤标本中，Tl-201的放射性核素摄取也较高。在早期和延迟图像上有明显Tl-201摄取的病变有大量Ki-67和PCNA阳性染色细胞。因此，Tl-201洗脱率低的病变很好地反映了肿瘤组织中更具活力的病变。结论是，通过Tl-201 SPECT的系列研究可以检测包括间变改变的神经胶质瘤的生存能力以及神经胶质瘤对治疗的反应。
