通过接受者操作特征分析对神经胶质瘤进行铊-201和锝-99m甲氧基异丁基异腈单光子发射计算机断层扫描的直接比较。

Direct comparison of thallium-201 and technetium-99m MIBI SPECT of a glioma by receiver operating characteristic analysis.

作者信息

Shibata Y, Yamamoto T, Takano S, Katayama W, Takeda T, Matsumura A

机构信息

Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-0005, Japan.

出版信息

J Clin Neurosci. 2009 Feb;16(2):264-9. doi: 10.1016/j.jocn.2008.04.010. Epub 2008 Dec 11.

DOI:10.1016/j.jocn.2008.04.010

PMID:19084414

Abstract

The diagnostic value of single photon-emission computed tomography (SPECT) has been assessed using arbitrarily determined sensitivity and specificity cut-off values. The diagnostic accuracy of thallium-201 (Tl-201) SPECT and technetium-99m methoxyisobutylisonitrile (Tc-MIBI) SPECT were compared for patients with primary glioma using receiver operating characteristic (ROC) analysis. The study population included 59 patients with gliomas. Tl and Tc-MIBI SPECT images were obtained using a multi-detector SPECT machine 15 min (early) and 3 hours (delayed) after intravenous injection of 74 MBq of Tl-chloride or 740 MBq of Tc-MIBI. The regions of interest were set on the tumor and contralateral normal white matter and tumor : normal ratios were calculated. The area z-score (A(z)) values were calculated from the areas under the ROC curves. All A(z) values were high and no statistical difference was observed between the two modalities. Both Tl and Tc-MIBI SPECT are useful imaging modalities for the evaluation of glioma malignancy.

摘要

单光子发射计算机断层扫描（SPECT）的诊断价值已使用任意确定的灵敏度和特异性临界值进行了评估。采用受试者工作特征（ROC）分析，比较了201铊（Tl-201）SPECT和99m锝甲氧基异丁基异腈（Tc-MIBI）SPECT对原发性胶质瘤患者的诊断准确性。研究人群包括59例胶质瘤患者。静脉注射74 MBq氯化铊或740 MBq Tc-MIBI后15分钟（早期）和3小时（延迟），使用多探测器SPECT机获取Tl和Tc-MIBI SPECT图像。在肿瘤和对侧正常白质上设置感兴趣区域，并计算肿瘤:正常比值。从ROC曲线下面积计算面积z评分（A(z)）值。所有A(z)值都很高，两种检查方法之间未观察到统计学差异。Tl和Tc-MIBI SPECT都是评估胶质瘤恶性程度的有用成像方法。