Paluch D, Staniszewska-Kuś J, Rutowski R, Szymonowicz M, Solski L
Zakład Chirurgii Eksperymentalnej i Badania Biomateriałów, Katedra Chirugii Urazowej Akademii Medycznej, Wrocławiu.
Polim Med. 1992;22(4):77-86.
Polyester vascular bilaterally velour prostheses produced by the Enterprise of Medical Products TRICOMED in Lodz were modified through: putting negative electric charge on the internal surfaces of prostheses; additional cleaning with ethanol; covering of the surfaces of prostheses with silicone preparation; two-sided covering of the surfaces of prostheses with collagen by the radiative method; covering of the surfaces of prostheses with chitosane. Laboratory investigations, investigations of hemolytic and toxic effects of aqueous as well as experimental investigations has been carried on piglets. During these investigations it was observed that the carried preparations caused multiple increase of electrical conductivity of proper and dry remnant after evaporation of the aqueous extracts. Hemolytic and toxic effects were not observed. In radiological and pathomorphological investigations it was observed that none of the preparations used for modification of vascular prostheses influenced improvement of their biological properties. In comparison with the initial prostheses DALLONR these prostheses evoked a greater reaction of tissues which was manifested with a thick internal layer causing narrowing of the lumen of the section with prosthesis or closing it. A small improvement of the biological properties of the prostheses were achieved after cleaning them with methanol. However, this improvement is so small that it does not justify changes in the existing technology.
罗兹的TRICOMED医疗产品企业生产的双侧天鹅绒聚酯血管假体通过以下方式进行了改性：在假体的内表面施加负电荷；用乙醇进行额外清洁；用硅酮制剂覆盖假体表面；通过辐射法用胶原蛋白对假体表面进行双面覆盖；用壳聚糖覆盖假体表面。对仔猪进行了实验室研究、水性提取物的溶血和毒性作用研究以及实验研究。在这些研究中观察到，所进行的制剂导致水提取物蒸发后适当和干燥残余物的电导率多次增加。未观察到溶血和毒性作用。在放射学和病理形态学研究中观察到，用于改性血管假体的任何制剂均未影响其生物学性能的改善。与初始假体DALLONR相比，这些假体引起了更大的组织反应，表现为内层增厚，导致带有假体的切片管腔变窄或闭合。用甲醇清洁假体后，假体的生物学性能有小幅改善。然而，这种改善非常小，不足以证明现有技术的改变是合理的。
