Crane M M, Godwin J E, Annegers J F, Keating M J
University of Texas Health Science Center School of Public Health, Houston 77225.
Cancer Epidemiol Biomarkers Prev. 1992 Mar-Apr;1(3):183-8.
The association between occupational and other environmental exposures was evaluated in 60 acute myelogenous leukemia cases and controls. Odds ratios and 95% confidence intervals for prior cytotoxic therapy and benzene exposure, adjusted for age, sex, and race by logistic regression, were 3.7 (0.7, 19.9) and 2.6 (0.4, 15.2), respectively. No other work-related associations, including employment in electrical occupations, were present. Other associations were suggestive but may have been due to biases in control selection or small numbers of subjects. The risks for prior cytotoxic therapy (odds ratio = 10.2) and benzene exposure (odds ratio = 11.4) were concentrated in 13 patients with French-American-British M4 leukemia; no environmental exposures were associated with French-American-British subtypes M1 and M2. These findings support the concept that French-American-British histological subtypes of AML may have different etiologies.
在60例急性髓性白血病病例及对照中评估职业及其他环境暴露之间的关联。通过逻辑回归对年龄、性别和种族进行校正后，既往细胞毒性治疗及苯暴露的比值比和95%置信区间分别为3.7（0.7，19.9）和2.6（0.4，15.2）。未发现包括电气职业就业在内的其他与工作相关的关联。其他关联具有提示性，但可能是由于对照选择中的偏倚或受试者数量较少所致。既往细胞毒性治疗（比值比=10.2）和苯暴露（比值比=11.4）的风险集中在13例法美英M4型白血病患者中；未发现环境暴露与法美英M1和M2亚型相关。这些发现支持了急性髓性白血病法美英组织学亚型可能具有不同病因的概念。
