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泰国白血病的危险因素。

Risk factors for leukemia in Thailand.

作者信息

Kaufman David W, Anderson Theresa E, Issaragrisil Surapol

机构信息

Slone Epidemiology Center, Boston University, Boston, MA, USA.

出版信息

Ann Hematol. 2009 Nov;88(11):1079-88. doi: 10.1007/s00277-009-0731-9. Epub 2009 Mar 18.

Abstract

A case-control study of adult-onset leukemia was conducted in Bangkok, Thailand to explore the contribution of cellular telephone use and other factors to the etiology of the disease; 180 cases (87 acute myeloblastic leukemia, 40 acute lymphoblastic leukemia, 44 chronic myelogenous leukemia, eight chronic lymphocytic leukemia, one unclassified acute leukemia) were compared with 756 age- and sex-matched hospital controls. Data were obtained by interview; odds ratios (ORs) were estimated by unconditional logistic regression. There was no clear association with cellular telephone phone use, but durations were relatively short (median 24-26 months), and there was a suggestion that risk may be increased for those with certain usage practices (ORs, 1.8-3.0 with lower confidence intervals >1.0) and those who used GSM service (OR, 2.1; 95% confidence interval, 1.1-4.0). Myeloid leukemia (acute and chronic combined) was associated with benzene (OR, 3.9; 95% confidence interval, 1.3-11), a nonspecific group of other solvents (2.3; 1.1-4.9), occupational pesticides that were mostly unspecified (3.8; 2.1-7.1), and working with or near powerlines (4.3; 1.3-15). No associations were found for diagnostic X-rays, cigarette smoking, or other occupational exposures.

摘要

在泰国曼谷开展了一项关于成人白血病的病例对照研究,以探究使用移动电话及其他因素对该疾病病因的影响。研究将180例患者(87例急性髓细胞白血病、40例急性淋巴细胞白血病、44例慢性粒细胞白血病、8例慢性淋巴细胞白血病、1例未分类的急性白血病)与756名年龄和性别匹配的医院对照者进行了比较。通过访谈获取数据;采用无条件逻辑回归估计比值比(OR)。结果发现使用移动电话与白血病之间无明确关联,但使用时长相对较短(中位数为24 - 26个月),且有迹象表明某些使用方式的人群(OR为1.8 - 3.0,较低置信区间>1.0)以及使用GSM服务的人群(OR为2.

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