Carsenti-Etesse H, Entenza J, Durant J, Pradier C, Mondain V, Bernard E, Dellamonica P
Department of Infectious Diseases, Archet Hospital, Nice, France.
Drugs Exp Clin Res. 1992;18(10):415-22.
Adhesion is the first step leading to colonization and infection of a foreign body (FBI). To assess the ability of a subinhibitory concentration (subMIC) of pefloxacin (P) to prevent such infection, an experimental model was developed in Swiss albino mice. Subcuts of polyurethane catheters (Vygon) were placed in the peritoneal cavity of animals and 24 hours later, different inocula of an adherent strain of Staphylococcus aureus (SA) (MIC of P:0.8 mg/l) were injected i.p. Unexposed SA served as controls. Two days later the removed catheters, blood and spleen specimens were quantitatively cultured for bacterial content and identity. Infection was defined as more than 10 CFU/ml of SA recovered. Significant protection of mice, with lower dissemination, was found with inoculum sizes of 10(5) and 10(6). These results suggest that subMICs of P may confer protection against foreign body infection.
黏附是导致异物（FBI）定植和感染的第一步。为了评估培氟沙星（P）的亚抑菌浓度（subMIC）预防此类感染的能力，在瑞士白化小鼠中建立了一个实验模型。将聚氨酯导管（Vygon）皮下植入动物腹腔，24小时后，腹腔注射不同接种量的金黄色葡萄球菌（SA）黏附菌株（P的MIC：0.8mg/l）。未接触SA的作为对照。两天后，对取出的导管、血液和脾脏标本进行细菌含量和种类的定量培养。感染定义为回收的SA超过10 CFU/ml。接种量为10⁵和10⁶时，发现对小鼠有显著保护作用，且传播较少。这些结果表明，P的亚抑菌浓度可能对异物感染具有保护作用。
