Hostacká A, Majtán V
Institute of Preventive and Clinical Medicine, Bratislava, Slovakia.
Folia Microbiol (Praha). 1994;39(3):197-202. doi: 10.1007/BF02814648.
The effects of subinhibitory concentrations (1/4, 1/8, 1/16 of the MIC) of 12 organic ammonium salts of A (hard-alkyltrimethylammonium bromides) and B (soft--2-(dodecanoylamino)ethylalkyldimethylammonium bromides) homologous series on phospholipase C, proteinase, elastase and permeability activity were studied. The substances with longer substituents were more effective in reducing phospholipase C activity (hard and soft series) as well as proteinase (hard series). Phospholipase C was the most frequently and the most markedly inhibited enzyme. The organic ammonium salts were less effective in inhibiting elastase and permeability activity. Only one of the substances under study reduced all the tested activities.
研究了A（硬烷基三甲基溴化铵）和B（软 - 2 - （十二烷酰氨基）乙基烷基二甲基溴化铵）同系物的12种有机铵盐的亚抑制浓度（MIC的1/4、1/8、1/16）对磷脂酶C、蛋白酶、弹性蛋白酶和通透性活性的影响。具有较长取代基的物质在降低磷脂酶C活性（硬系列和软系列）以及蛋白酶（硬系列）方面更有效。磷脂酶C是最常被抑制且抑制最明显的酶。有机铵盐在抑制弹性蛋白酶和通透性活性方面效果较差。所研究的物质中只有一种降低了所有测试的活性。
