Söylemezoğlu O, Tinaztepe K, Bakkaloğlu A, Saatçi U
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.
Turk J Pediatr. 1992 Oct-Dec;34(4):211-7.
Idiopathic membranoproliferative glomerulonephritis (MPGN) is a chronic renal disease with variable clinical expression and several distinct morphological subtypes. Two sibs, aged 10 and 13, presented with clinical and laboratory findings of MPGN at the time of admission. After an interval of one year, the diagnosis of MPGN was established by renal biopsies. The complement pathway was unremarkable. HLA typing in the unrelated parents and the two male sibs revealed common HLA A2,A11,Bw60, DR2,DQw1 antigens in the brothers. Of these antigens, A2 has been reported previously in cases of MPGN. The other antigens regarding this disease need to be evaluated from the standpoint of genetic importance.
特发性膜增生性肾小球肾炎（MPGN）是一种临床表现多样且有几种不同形态学亚型的慢性肾脏疾病。两名分别为10岁和13岁的兄弟在入院时出现了MPGN的临床和实验室检查结果。一年后，通过肾活检确诊为MPGN。补体途径无异常。对无关父母及这两名兄弟进行的HLA分型显示，兄弟俩有共同的HLA A2、A11、Bw60、DR2、DQw1抗原。在这些抗原中，A2此前已有在MPGN病例中出现的报道。关于这种疾病的其他抗原需要从遗传学重要性的角度进行评估。
