Komori K, Nose Y, Inouye H, Tsuji K, Nomoto Y, Tomino Y, Sakai H, Iwagaki H, Itoh H, Hasegawa O
Tokai J Exp Clin Med. 1983 May;8(2):135-48.
HLA-A, B and DR typing was performed on a total of 236 patients with chronic glomerulonephritis (CGN) which were diagnosed by renal biopsies evaluated by light microscopy, direct immunofluorescent staining and whenever indicated electron microscopy. The interrelationship between the HLA system and the histopathologic classification of CGN was examined. There were 20 patients with benign recurrent hematuria (BRH), 82 with IgA nephropathy (IgA-N), 24 with proliferative glomerulonephritis (PGN), 47 with minimal change nephrotic syndrome (MCNS), 4 with membranous nephropathy (MN), 43 with membranoproliferative glomerulonephritis (MPGN) and 16 with focal glomerulosclerosis (FGS). The following results were obtained: 1) Antigens from different loci were associated with different subgroups of CGN. There were three types of associations; a) HLA-A locus associated as found in PGN, b) HLA-B locus associated as found in BRH and c) HLA-DR locus associated as found in MCNS. IgA-N, MPGN and FGS seemed to be included in this group. 2) The association of HLA-A locus antigens with MCNS could be subdivided by age o onset suggesting that in MCNS HLA-A antigens are linked to disease expression. 3) A heterogeneity in IgA-N is suggested by its association with different HLA antigens; a) a HLA-B37 associated group, b) a HLA-DR4 or DYT associated group and c) a HLA-DEn (Dw 6.1) or B12 associated group. These data suggest differences in the mechanisms of HLA and disease association in each histopathologic subtype of CGN.
对236例慢性肾小球肾炎（CGN）患者进行了HLA - A、B和DR分型，这些患者均经肾活检确诊，肾活检采用光镜、直接免疫荧光染色评估，必要时采用电子显微镜检查。研究了HLA系统与CGN组织病理学分类之间的相互关系。其中有20例良性复发性血尿（BRH）患者、82例IgA肾病（IgA - N）患者、24例增殖性肾小球肾炎（PGN）患者、47例微小病变肾病综合征（MCNS）患者、4例膜性肾病（MN）患者、43例膜增殖性肾小球肾炎（MPGN）患者和16例局灶性肾小球硬化（FGS）患者。获得了以下结果：1）来自不同位点的抗原与CGN的不同亚组相关。存在三种关联类型：a）如在PGN中发现的与HLA - A位点相关，b）如在BRH中发现的与HLA - B位点相关，c）如在MCNS中发现的与HLA - DR位点相关。IgA - N、MPGN和FGS似乎也属于这一组。2）HLA - A位点抗原与MCNS的关联可按发病年龄细分，提示在MCNS中HLA - A抗原与疾病表达相关。3）IgA - N与不同HLA抗原的关联提示其存在异质性：a）HLA - B37相关组，b）HLA - DR4或DYT相关组，c）HLA - DEn（Dw 6.1）或B12相关组。这些数据表明，在CGN的每种组织病理学亚型中，HLA与疾病关联的机制存在差异。
