脑5-羟色胺能系统对雄性大鼠催乳素分泌的刺激作用。

Stimulatory role for brain serotoninergic system on prolactin secretion in the male rat.

作者信息

Gil-ad I, Zambotti F, Carruba M O, Vicentini L, Müller E E

出版信息

Proc Soc Exp Biol Med. 1976 Mar;151(3):512-8. doi: 10.3181/00379727-151-39247.

Abstract

Systemic administration of parachlorophenylalanine (PCPA, 100 mg/kg sc on alternate days X two times), a blocker of serotonin (5-HT) synthesis, considerably decreased brain 5-HT and plasma prolactin (PRL) levels in young male rats. Intraventricular (IVT) administration of 5,7-dihydroxytryptamine (5,7-DHT, 200 mug/20 mul), a neurotoxic drug which destroys 5-HT nerve terminals, induced, 3, 12, and 30 days after treatment, a marked depletion of brain 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) and considerably reduced plasma PRL levels at each time interval. Feeding of rat for up to 4 days with a tryptophan (TP)-deficient diet, caused a depletion of brain 5-HT and 5-HIAA contents and did not modify plasma PRL levels. Addition of TP (2 g/kg of diet) to the TP-deficient diet resulted in increased brain 5-HT and 5-HIAA contents and significantly increased PRL levels. These data provide evidence for the role of the 5-HT system in the maintenance of tonic PRL secretion.

摘要

对年轻雄性大鼠隔日皮下注射100毫克/千克对氯苯丙氨酸（PCPA，共注射两次），一种血清素（5 - HT）合成阻滞剂，可显著降低其脑内5 - HT和血浆催乳素（PRL）水平。脑室内（IVT）注射5,7 - 二羟基色胺（5,7 - DHT，200微克/20微升），一种破坏5 - HT神经末梢的神经毒性药物，在治疗后3天、12天和30天，可导致脑内5 - HT和5 - 羟基吲哚乙酸（5 - HIAA）显著耗竭，并在每个时间间隔均使血浆PRL水平大幅降低。用缺乏色氨酸（TP）的饲料喂养大鼠长达4天，可导致脑内5 - HT和5 - HIAA含量耗竭，且不改变血浆PRL水平。在缺乏TP的饲料中添加TP（2克/千克饲料），可使脑内5 - HT和5 - HIAA含量增加，并显著提高PRL水平。这些数据为5 - HT系统在维持催乳素基础分泌中的作用提供了证据。