Das K P, Das P C, Dasgupta S, Dey C D
Department of Microbiology, Howard University Cancer Center, Washington, DC 20060.
Biol Trace Elem Res. 1993 Feb;36(2):119-27. doi: 10.1007/BF02783170.
Daily subcutaneous injection of cadmium chloride (0.3 mg/100g bw) for two weeks to normal and protein restricted (5% casein) rats shows significant decrease in 5-HT concentration in cerebellum, medulla oblongata-pons, hypothalamus, striatum-hippocampus, midbrain-thalamus-subthalamus, and cortex in both dietary regimens. No significant change occurs in concentration of ACh in cerebellum, but there is a significant increase in cortex, whereas significant decrease occurs in rest of the discrete regions of brain in both dietary conditions. Results also indicate that the intensity of cadmium effect is more evident in discrete brain regions in protein restricted dietary condition than in the normal group. The inhibitory action of Cd on both neurotransmitters has been discussed.
对正常和蛋白质限制（5%酪蛋白）饮食的大鼠，每日皮下注射氯化镉（0.3毫克/100克体重），持续两周，结果显示，在两种饮食方案下，小脑、延髓-脑桥、下丘脑、纹状体-海马、中脑-丘脑-下丘脑和皮质中的5-羟色胺浓度均显著降低。小脑内乙酰胆碱浓度无显著变化，但皮质中显著升高，而在两种饮食条件下，大脑其他离散区域均显著降低。结果还表明，在蛋白质限制饮食条件下，镉对离散脑区的影响强度比正常组更明显。文中讨论了镉对这两种神经递质的抑制作用。
