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[根据应用方法测定兔眼房水中庆大霉素浓度的价值。博士论文摘要]

[Value of gentamycin concentration in aqueous humor of a rabbit's eye depending on the method of application. Summary of a doctoral thesis].

作者信息

Philips R H

机构信息

Kliniki Okulistycznej AM, Poznaniu.

出版信息

Klin Oczna. 1992 Oct;94(10):279-81.

PMID:1306533
Abstract

Pharmacokinetics of gentamycin in the primary and secondary rabbit's aqueous was examined by using a new experimental method of subconjunctival application (without breaking the continuity of the conjunctiva). It was established that after subconjunctival application one cannot obtain any therapeutical concentrations in the primary or secondary aqueous. Presented are conditions which have to be fulfilled to obtain a therapeutical concentration of gentamycin in the secondary aqueous.

摘要

通过一种新的结膜下给药实验方法(不破坏结膜的连续性),研究了庆大霉素在兔眼房水(原发性和继发性)中的药代动力学。结果表明,结膜下给药后,在原发性或继发性房水中均无法获得任何治疗浓度。文中给出了在继发性房水中获得庆大霉素治疗浓度必须满足的条件。

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