Szymański A, Brozyna-Zyłka B, Sobieraj A, Otrzonsek D
Kliniki Okulistycznej Slaskiej Akademii Medycznej, Katowicach.
Klin Oczna. 1992 Oct;94(10):289-91.
Seventeen patients with glaucoma were given bilaterally a single drop of Isoglaucon (Clonidine hydrochloride) of various volume (15 microliters and 40 microliters) and various concentrations of the drug (0.125%, 0.25%, 0.50%) according to the principle of a double blind trial. In comparison with placebo all sorts of Isoglaucon drops cause a statistically important reduction of intraocular pressure; an essential lowering of the general systolic and diastolic pressure (a side effect of the treatment) appeared after application of a larger drop (40 microliters) of a 0.5% concentration. By reducing the content of the drug in the drop or reducing its volume one can avoid the fall in the general blood pressure.
按照双盲试验原则，对17名青光眼患者双侧各滴入一滴不同体积（15微升和40微升）、不同浓度（0.125%、0.25%、0.50%）的异可乐定（盐酸可乐定）。与安慰剂相比，各种异可乐定滴眼液均能使眼压在统计学上显著降低；在滴入0.5%浓度的较大剂量滴眼液（40微升）后，出现了收缩压和舒张压的显著下降（治疗的副作用）。通过减少滴眼液中的药物含量或降低其体积，可以避免全身血压下降。
