Busse H, Jünemann G, Lienert F
Klin Monbl Augenheilkd. 1976 Jun;168(6):832-5.
From 15 eyes in 12 patients with chronic simple glaucoma a comparison of the IOP-diminishing effect between 1 drop 0.25% aqueous solution of Clonidine and a 2 cm long application of 0.2% Clonidine-ointment was made with special regard of local and general side effects, especially on the blood pressure. The reduction of the IOP and the blood pressure was greater and of longer duration after ointment application has a definite depôt-effect. Older patients should be fully digitalized beforehand in order to support the cardiovascular system during Clonidine application.
对12例慢性单纯性青光眼患者的15只眼睛进行了比较，观察0.25%可乐定水溶液一滴与2厘米长的0.2%可乐定软膏应用后眼压降低效果，并特别关注局部和全身副作用，尤其是对血压的影响。应用软膏后眼压和血压的降低幅度更大且持续时间更长，具有明显的储库效应。老年患者应预先充分进行洋地黄化，以便在应用可乐定时支持心血管系统。
