Idzior-Waluś B
Katedry Diagnostyki Biochemicznej, AM w Krakowie.
Przegl Lek. 1992;49(11):365-8.
Serum cortisol and insulin concentrations were determined in 30 patients with primary hyperlipoproteinemia (HLP) phenotype IIa (20 persons) and IIb (10 persons) during treatment with lovastatin. Lovastatin dosage varied from 20-80 mg daily. Serum insulin concentration did not change significantly after lovastatin treatment. Serum cortisol concentration significantly increased after 12 weeks of treatment. Cortisol concentration changes were different in HLP IIa and IIb patients. In HLP IIa cortisol concentration increased from 21.9 micrograms/dl to 28.1 micrograms/dl after 12 weeks of treatment, in HLP IIb cortisol level decreased from 31.3 to 24.1 micrograms/dl after 4 weeks of treatment and increased to 32.3 micrograms/dl after 12 weeks of therapy. Mean cortisol concentration was significantly higher in HLP IIa than HLP IIb patients. LDL-cholesterol concentrations changes after treatment correlated significantly with baseline cortisol concentration in HLP IIa group (r = -.34), changes in HDL-cholesterol concentration with baseline insulin levels in HLP IIb patients (r = -.54).
对30例原发性高脂蛋白血症（HLP）IIa型（20例）和IIb型（10例）患者在使用洛伐他汀治疗期间测定了血清皮质醇和胰岛素浓度。洛伐他汀剂量为每日20 - 80毫克。洛伐他汀治疗后血清胰岛素浓度无显著变化。治疗12周后血清皮质醇浓度显著升高。HLP IIa型和IIb型患者的皮质醇浓度变化不同。在HLP IIa型患者中，治疗12周后皮质醇浓度从21.9微克/分升升至28.1微克/分升；在HLP IIb型患者中，治疗4周后皮质醇水平从31.3微克/分升降至24.1微克/分升，治疗12周后升至32.3微克/分升。HLP IIa型患者的平均皮质醇浓度显著高于HLP IIb型患者。HLP IIa组治疗后低密度脂蛋白胆固醇浓度变化与基线皮质醇浓度显著相关（r = -0.34），HLP IIb型患者高密度脂蛋白胆固醇浓度变化与基线胰岛素水平相关（r = -0.54）。
