[Influence of lovastatin on serum lipids in patients with primary hyperlipidemia and phenotype IIa and IIB. II. Changes of lipid composition of plasma lipoprotein fractions after lovastatin administration].

In this study lipid composition of lipoprotein fractions LDL, VLDL and HDL was determined in 30 men with primary hyperlipoproteinemia phenotype IIa and IIb during lovastatin treatment. After 12 weeks of treatment in VLDL and LDL fractions decrease of percentage of cholesterol content and increase percentage of protein content was observed. The percentage of esterified cholesterol decreased in VLDL fraction and increased in LDL fraction during treatment. In HLP IIa significant decrease of percentage cholesterol content in VLDL and LDL fraction was observed. In HLP IIb decrease of percentage cholesterol content in VLDL and increase in percentage triglyceride content was found. Esterified cholesterol percentage decreased in VLDL fraction in HLP IIa. Lipids to protein ratio decreased significantly during treatment in VLDL and LDL fraction. The results of this study indicate that hypolipidemic treatment with lovastatin is associated with changes in lipid composition of lipoproteins, mainly with the decrease of percentage cholesterol content.