Idzior-Waluś B
Katedry Diagnostyki Biochemicznej, AM w Krakowie.
Przegl Lek. 1992;49(10):327-33.
In this study lipid composition of lipoprotein fractions LDL, VLDL and HDL was determined in 30 men with primary hyperlipoproteinemia phenotype IIa and IIb during lovastatin treatment. After 12 weeks of treatment in VLDL and LDL fractions decrease of percentage of cholesterol content and increase percentage of protein content was observed. The percentage of esterified cholesterol decreased in VLDL fraction and increased in LDL fraction during treatment. In HLP IIa significant decrease of percentage cholesterol content in VLDL and LDL fraction was observed. In HLP IIb decrease of percentage cholesterol content in VLDL and increase in percentage triglyceride content was found. Esterified cholesterol percentage decreased in VLDL fraction in HLP IIa. Lipids to protein ratio decreased significantly during treatment in VLDL and LDL fraction. The results of this study indicate that hypolipidemic treatment with lovastatin is associated with changes in lipid composition of lipoproteins, mainly with the decrease of percentage cholesterol content.
在本研究中，对30例原发性IIa型和IIb型高脂蛋白血症男性患者在洛伐他汀治疗期间脂蛋白组分低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）和高密度脂蛋白（HDL）的脂质组成进行了测定。治疗12周后，观察到VLDL和LDL组分中胆固醇含量百分比降低，蛋白质含量百分比增加。治疗期间，VLDL组分中酯化胆固醇百分比降低，LDL组分中酯化胆固醇百分比增加。在IIa型高脂蛋白血症（HLP IIa）中，观察到VLDL和LDL组分中胆固醇含量百分比显著降低。在IIb型高脂蛋白血症（HLP IIb）中，发现VLDL中胆固醇含量百分比降低，甘油三酯含量百分比增加。在HLP IIa中，VLDL组分中酯化胆固醇百分比降低。治疗期间，VLDL和LDL组分中脂质与蛋白质的比率显著降低。本研究结果表明，洛伐他汀的降血脂治疗与脂蛋白脂质组成的变化有关，主要是胆固醇含量百分比的降低。
