Ni D T, Sun B
Department of Respiratory Diseases, Xijing Hospital, Fourth Military Medical University, Xian.
Zhonghua Nei Ke Za Zhi. 1992 Dec;31(12):744-7, 779.
Bronchoalveolar lavage (BAL) was performed in healthy subjects (n = 12) and patients with bronchial asthma (n = 11). Between the two groups there was no significant difference in the total number of cells and the percentage of alveolar macrophages (AM), lymphocytes (L), neutrophils (N) and eosinophils (E) in BAL fluids. When AM were cultured in vitro and stimulated with dermatophagoides farinae (DPF) antigen, the amount of PGE released by AM was significantly increased in the asthmatics. When the asthmatics, AM were sensitized with specific IgE positive serum and stimulated with DPF, they released more PGE and PGF2 alpha than those when specific IgE negative serum was used (P < 0.01). The PGE/PGF2 alpha ratio was significantly decreased. There was positive correlation between the decreased value of PGE/PGF2 alpha and patients, MCH-PC20. The increase in the amount of PGE and PGF2 alpha released and the decrease of PGE/PGF2 alpha ratio might play an important role in the pathogenesis of allergic asthma.
对健康受试者（n = 12）和支气管哮喘患者（n = 11）进行了支气管肺泡灌洗（BAL）。两组之间，BAL液中的细胞总数以及肺泡巨噬细胞（AM）、淋巴细胞（L）、中性粒细胞（N）和嗜酸性粒细胞（E）的百分比无显著差异。当AM在体外培养并用粉尘螨（DPF）抗原刺激时，哮喘患者AM释放的PGE量显著增加。当哮喘患者的AM用特异性IgE阳性血清致敏并用DPF刺激时，与使用特异性IgE阴性血清相比，它们释放更多的PGE和PGF2α（P < 0.01）。PGE/PGF2α比值显著降低。PGE/PGF2α的降低值与患者的MCH-PC20呈正相关。PGE和PGF2α释放量的增加以及PGE/PGF2α比值的降低可能在过敏性哮喘的发病机制中起重要作用。
