Kitakado Y, Tanaka K, Asonuma K, Uemoto S, Matsuoka S, Utsunomiya H, Okamura R, Katayama T, Inomata Y, Ozawa K
Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Nihon Geka Hokan. 1992 Nov 1;61(6):445-53.
Rat vascular anastomosis was performed using a newly synthesized bioabsorbable material (LA-GA copolymer) cuffs and the ordinary polyethylene cuffs. The LA-GA copolymer cuff which anastomosed the portal vein and the inferior vena cava were patent and developed no collateral veins even after 6 months, keeping the transplanted liver normal. By contrast, the polyethylene cuff anastomosed portal vein was completely occluded and the collateral veins were highly developed, with the transplanted liver showing the fatty degeneration of hepatocytes and numerous regenerative nodules. It is concluded that the LA-GA copolymer cuff is a suitable material for the short and long term study of rat orthotopic liver transplantation.
使用新合成的生物可吸收材料（LA-GA共聚物）套管和普通聚乙烯套管进行大鼠血管吻合。吻合门静脉和下腔静脉的LA-GA共聚物套管通畅，即使在6个月后也未形成侧支静脉，移植肝保持正常。相比之下，聚乙烯套管吻合的门静脉完全闭塞，侧支静脉高度发达，移植肝出现肝细胞脂肪变性和大量再生结节。结论是，LA-GA共聚物套管是大鼠原位肝移植短期和长期研究的合适材料。
