Kitakado Y, Tanaka K, Asonuma K, Uemoto S, Matsuoka S, Utsunomiya H, Okamoto R, Katayama T, Inomata Y, Ozawa K
Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Eur Surg Res. 1991;23(5-6):366-70. doi: 10.1159/000129177.
Rat orthotopic liver transplantation was performed using a newly synthesized bioabsorbable material (LA-GA copolymer) cuffs and the ordinary polyethylene cuffs. The LA-GA copolymer cuff which anastomosed the portal vein was patent and developed no collateral veins even after 6 months, keeping the transplanted liver normal. By contrast, the polyethylene cuff-anastomosed portal vein was completely occluded and the collateral veins were highly developed, with the transplanted liver showing the fatty degeneration of hepatocytes and numerous regenerative nodules. It is concluded that the LA-GA copolymer cuff is a suitable material for the short- and long-term study of rat orthotopic liver transplantation.
采用新合成的生物可吸收材料（LA-GA共聚物）套管和普通聚乙烯套管进行大鼠原位肝移植。吻合门静脉的LA-GA共聚物套管通畅，即使在6个月后也未形成侧支静脉，移植肝保持正常。相比之下，聚乙烯套管吻合的门静脉完全闭塞，侧支静脉高度发达，移植肝出现肝细胞脂肪变性和大量再生结节。得出结论，LA-GA共聚物套管是大鼠原位肝移植短期和长期研究的合适材料。
