Dantas R O, Lôbo C J, Ferriolli E, Matsuda N M
Departamento de Clínica Médica da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, USP.
Arq Gastroenterol. 1992 Apr-Jun;29(2):39-42.
We studied the effect of aging on lower esophageal sphincter (LES) pressure of 52 normal subjects, 129 patients with Chagas' disease and 63 patients with systemic sclerosis. Three groups were compared: with ages between 10 to 29 years, 30 to 49 years and 50 to 70 years. We used a perfused catheter and the station pull-through (SPT) technique, at end expiratory phase. There was no difference in LES pressure between the three groups in normal subjects (p = 0.72) and patients with systemic sclerosis (p = 0.33). In Chagas' disease the patients with ages between 50 to 70 years had LES pressure (17 +/- 8 mmHg, mean +/- SD) lower (p = 0.03) than patients with ages between 10 to 29 years (22 +/- 9 mmHg). We conclude that in Chagas' disease the patients with ages over 50 years have LES pressure lower than patients with ages under 30 years, what does not happen with normal subjects nor systemic sclerosis patients.
我们研究了衰老对52名正常受试者、129名恰加斯病患者和63名系统性硬化症患者下食管括约肌（LES）压力的影响。比较了三组人群：年龄在10至29岁、30至49岁和50至70岁之间。我们在呼气末阶段使用灌注导管和牵伸通过（SPT）技术。在正常受试者（p = 0.72）和系统性硬化症患者（p = 0.33）中，三组之间的LES压力没有差异。在恰加斯病中，年龄在50至70岁之间的患者LES压力（17±8 mmHg，平均值±标准差）低于年龄在10至29岁之间的患者（22±9 mmHg，p = 0.03）。我们得出结论，在恰加斯病中，年龄超过50岁的患者LES压力低于30岁以下的患者，而正常受试者和系统性硬化症患者则没有这种情况。
