Dantas R O, Rezende Filho J, de Oliveira R B, de Godoy R A
Departamento de Clinica Médica, Faculdade de Medicina, Universidade de São Paulo, Ribeirão Preto.
Arq Gastroenterol. 1987 Apr-Jun;24(2):84-7.
The effect of 5 mg of sublingual isosorbide dinitrate on the lower esophageal sphincter pressure of 28 chagasic patients with esophageal involvement, was studied by continuous perfusion manometry. The pressure was measured at 5 minute intervals for 60 minutes after drug administration. Isosorbide dinitrate reduced sphincter pressure from 5 to 60 minutes (p less than 0.01). Only two patients hadn't sphincter pressure reduced lower than 50% of initial value at 20 minutes after drug administration. These results indicate that isosorbide dinitrate may be useful to reduce lower esophageal sphincter pressure in chagasic megaesophagus.
通过连续灌注测压法研究了5毫克舌下含服硝酸异山梨酯对28例患有食管受累的恰加斯病患者下食管括约肌压力的影响。给药后每隔5分钟测量一次压力，共测量60分钟。硝酸异山梨酯在给药后5至60分钟降低了括约肌压力（p小于0.01）。只有两名患者在给药后20分钟时括约肌压力降低未低于初始值的50%。这些结果表明，硝酸异山梨酯可能有助于降低恰加斯病性巨食管患者的下食管括约肌压力。
