Jiang C L, Guan W B, Kong X T, Wang X L, Yan Y B
Department of Parasitology, Second Military Medical University, Shanghai.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1992;10(3):184-6.
The monoclonal antibody (McAb) designated as C6 against erythrocytic stage of Plasmodium falciparum Fcc7801/HN showed significant growth inhibition of P. falciparum in vitro, having cross immunofluorescence reaction with P. falciparum Fcc-1/HN, Fcc7802/HN, Fcc8703/JS and P. berghei, P. cynomolgi. McAb C6 bound to the antigen distributed evenly over the entire surface of merozoites of P. falciparum, as demonstrated by immunoelectron microscopy. The McAb C6 also recognized a single protein of 71 kDa of P. falciparum by Western blotting. This antigen might be a candidate of malaria vaccine.
名为C6的抗恶性疟原虫Fcc7801/HN红细胞期的单克隆抗体（McAb）在体外对恶性疟原虫显示出显著的生长抑制作用，与恶性疟原虫Fcc-1/HN、Fcc7802/HN、Fcc8703/JS以及伯氏疟原虫、食蟹猴疟原虫有交叉免疫荧光反应。免疫电镜显示，McAb C6与分布在恶性疟原虫裂殖子整个表面的抗原结合。通过蛋白质印迹法，McAb C6还识别出恶性疟原虫的一种71 kDa的单一蛋白质。该抗原可能是疟疾疫苗的一个候选物。
