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[电刺激治疗坐骨神经去神经大鼠胫骨骨质疏松症]

[Electrical stimulation in the treatment of osteoporosis in sciatic denervated rat tibia].

作者信息

Li M

机构信息

Changhai Hospital, Second Military Medical University, Shanghai.

出版信息

Zhonghua Wai Ke Za Zhi. 1992 Aug;30(8):458-60, 508.

PMID:1307307
Abstract

Osteoporosis in the sciatic-denervated rat tibia was reversed with a capacitively coupled electrical field. In the reversal of a previously established osteoporosis, a statistically significant enhancement of wet weight, dry weight, ashed weight, ultimate strength, cortical area, cortical thickness and a concomitant decrease in cortical porosity occurred in the stimulated, denervated tibiae of the experimental animals compared with the nonstimulated, denervated tibiae of the control animals. A 60 Hz symmetrical sinewave signal was effective in reversing osteoporosis at 10 V peak to peak. Reversal of a well-established osteoporosis in laboratory animals has not been reported previously.

摘要

通过电容耦合电场可逆转坐骨神经去神经支配大鼠胫骨的骨质疏松。在逆转先前已形成的骨质疏松过程中,与对照动物未受刺激的去神经支配胫骨相比,实验动物受刺激的去神经支配胫骨的湿重、干重、灰重、极限强度、皮质面积、皮质厚度有统计学意义的增加,同时皮质孔隙率降低。60赫兹对称正弦波信号在峰峰值为10伏时可有效逆转骨质疏松。此前尚未有在实验动物中逆转已形成的骨质疏松的报道。

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