Sert Cemil, Mustafa Deni, Düz M Zahir, Akşen Feyzan, Kaya Abdurrahman
Department of Biophysics, Medical School, Harran University, 63300, Yenişehir Kampüsü Sanliurfa, Turkey.
J Bone Miner Metab. 2002;20(6):345-9. doi: 10.1007/s007740200050.
Osteoporosis is a common health problem, especially in the elderly and in women after menopause. Although there are some treatment methods, they impose serious side effects. Recently, the use of an electromagnetic field (EMF) has been a promising candidate for better treatment of osteoporosis. In the present study, we investigated the preventive effects of low-frequency (50 Hz), low-intensity (1 mT), and long-term (6 weeks) EMF on bone loss in ovariectomized rats. We used 18 female albino Wistar rats (8 unexposed and 10 exposed) to assess the effect of EMF. We examined the mineralization and the morphology of the tibia in control and EMF-exposed rats. The cortical thickness of the tibia was increased in EMF-exposed rats ( P < 0.002). The levels of Na and K in the tibia were significantly increased in rats exposed to EMF ( P < 0.001; P < 0.002, respectively). We also observed an increased blood alkaline phosphatase (ALP) level after EMF exposure ( P < 0.05). No significant differences in the levels of Ca, Mg, Li, or creatine were found between the exposed and unexposed groups. Our data support the notion that an EMF may prove to be an effective treatment method for osteoporosis and other abnormalities related to bone loss.
骨质疏松症是一个常见的健康问题，尤其在老年人以及绝经后的女性中。尽管存在一些治疗方法，但它们会带来严重的副作用。最近，使用电磁场（EMF）已成为更好治疗骨质疏松症的一个有前景的选择。在本研究中，我们调查了低频（50赫兹）、低强度（1毫特斯拉）和长期（6周）电磁场对去卵巢大鼠骨质流失的预防作用。我们使用18只雌性白化Wistar大鼠（8只未暴露和10只暴露）来评估电磁场的作用。我们检查了对照组和暴露于电磁场的大鼠胫骨的矿化情况和形态。暴露于电磁场的大鼠胫骨皮质厚度增加（P < 0.002）。暴露于电磁场的大鼠胫骨中钠和钾的水平显著升高（分别为P < 0.001；P < 0.002）。我们还观察到暴露于电磁场后血液碱性磷酸酶（ALP）水平升高（P < 0.05）。在暴露组和未暴露组之间，钙、镁、锂或肌酸水平未发现显著差异。我们的数据支持这样一种观点，即电磁场可能被证明是治疗骨质疏松症以及其他与骨质流失相关异常情况的有效治疗方法。
