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[激光多普勒测量人体耳蜗血流:初步结果]

[The measurement of cochlear flow by laser Doppler in man: the preliminary results].

作者信息

Albera R, Magnano M, De Siena L, Orecchia C, Bolognese P, Pignocchino P, Cortesina G

机构信息

II Clinica ORL, Università di Torino.

出版信息

Acta Otorhinolaryngol Ital. 1992 Nov-Dec;12(6):553-64.

PMID:1307446
Abstract

Laser-Doppler flowmetry is presently one of the methods of choice in measuring cochlear blood flow. The techniques is non-invasive and is based on the frequency shift of the laser beam induced by the red blood cell movement. Previous studies of cochlear blood flow carried out on animals and humans demonstrated the reliability of laser-Doppler flowmetry and its usefulness in understanding inner ear microcirculation physiology. In this paper we present preliminary data obtained from three patients examined under general anesthesia while undergoing tympanoplasty. Results showed that tracings, whose baseline is proportional with the blood flow, are characterized by waves correlated to pulse beat and automatic ventilation. Moreover, intrinsic contractions of inner ear vessels (waves of vasomotion) as exist in cerebral microcirculation, were observed. Pharmacological hypotension hypocapnia and the application of epinephryne determine a significant reduction of cochlear blood flow. These results suggest that while cochlear blood flow is related to systemic pressure, it has an intrinsic control system. As well since we did not obtain any modification in bone conduction threshold after surgery, we conclude that laser-Doppler flowmetry is a safe technique.

摘要

激光多普勒血流测量法目前是测量耳蜗血流的首选方法之一。该技术是非侵入性的,基于红细胞运动引起的激光束频移。先前对动物和人类进行的耳蜗血流研究证明了激光多普勒血流测量法的可靠性及其在理解内耳微循环生理学方面的实用性。在本文中,我们展示了从三名在全身麻醉下接受鼓室成形术检查的患者获得的初步数据。结果表明,其基线与血流成比例的描记图的特征是与脉搏跳动和自动通气相关的波。此外,还观察到了内耳血管的内在收缩(血管运动波),这与脑微循环中存在的情况相同。药物性低血压、低碳酸血症以及肾上腺素的应用会导致耳蜗血流显著减少。这些结果表明,虽然耳蜗血流与全身压力有关,但它有一个内在控制系统。同样,由于我们在手术后未观察到骨传导阈值有任何变化,我们得出结论,激光多普勒血流测量法是一种安全的技术。

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