Futenma A
Rinsho Byori. 1992 Oct;40(10):1027-33.
To study the role of reactive oxygen species (ROS) in chronic renal disease, we studied the localization of Cu, Zn-superoxide dismutase (SOD) in glomeruli of patients with IgA nephropathy by immunohistochemistry on 37 kidney specimens consisting of 32 IgA nephropathy and normal parts of the 5 resected kidneys with renal tumors serving as controls. To evaluate the change in renal function, creatinine clearance (Ccr) was assessed at the time of biopsy and 1 year after the biopsy. In the normal kidney, Cu, Zn-SOD was localized in the tubular cells, and not in the glomeruli. In the kidney with IgA nephropathy, Cu, Zn-SOD was detected on the epithelial side of the glomerular capillary wall in addition to the tubular cells. The extent of localization of this enzyme was compared with the clinical findings at the time of biopsy. When Cu, Zn-SOD was stained strongly in the glomeruli, the histological change of the glomeruli was milder, and the renal function appeared to be more preserved; the decrease in Ccr one year after the renal biopsy was inhibited. These findings suggest that Cu, Zn-SOD has beneficial actions for renal function as anti-oxidative factors.
为研究活性氧（ROS）在慢性肾病中的作用，我们采用免疫组织化学方法，对37份肾脏标本（其中包括32份IgA肾病标本以及5份因肾肿瘤而切除的肾脏的正常部分，后者作为对照）中IgA肾病患者肾小球内铜锌超氧化物歧化酶（SOD）的定位进行了研究。为评估肾功能变化，在活检时及活检后1年测定肌酐清除率（Ccr）。在正常肾脏中，铜锌超氧化物歧化酶定位于肾小管细胞，而非肾小球。在IgA肾病肾脏中，除肾小管细胞外，在肾小球毛细血管壁的上皮侧也检测到了铜锌超氧化物歧化酶。将该酶的定位程度与活检时的临床发现进行比较。当肾小球中铜锌超氧化物歧化酶染色强烈时，肾小球的组织学变化较轻，肾功能似乎得到更好的保留；肾活检1年后Ccr的下降受到抑制。这些发现表明，铜锌超氧化物歧化酶作为抗氧化因子对肾功能具有有益作用。
