Ambros R A
Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland.
Mater Med Pol. 1992 Apr-Jun;24(2):76-8.
Expression of a c-myc proto-oncogene product known as p62 (c-myc) was studied in 18 cases of stage I endometrioid (typical) adenocarcinoma of the uterus by immunohistochemistry and correlated with mucin production and other pathologic features. Cytoplasmic staining of tumor cells for c-myc product was seen in all cases and nuclear staining in three cases. Endometrial stromal cells were invariably negative and myometrial nuclear staining was seen in three cases. Within the tumor itself, whereas intense staining was frequent in high grade tumors with deep myometrial and vascular invasion, faint to moderate staining was frequent in well differentiated tumors with superficial myometrial invasion. A general tendency was also seen for greater staining in the myometrial component of the tumor than in tumor located in the endometrium. Whereas staining in the latter was frequently patchy in distribution, c-myc expression was invariably uniform in the myometrial component. Mucin production was somewhat greater in endometrial than myometrial components but did not correlate with c-myc expression or other pathologic features. This study demonstrates that c-myc is variably expressed in endometrial carcinoma and high c-myc expression can be associated with populations of tumor cells selectively capable of myometrial and vascular invasion.
通过免疫组织化学方法，对18例Ⅰ期子宫内膜样（典型）子宫腺癌中一种名为p62（c-myc）的c-myc原癌基因产物的表达进行了研究，并将其与黏蛋白产生及其他病理特征相关联。所有病例均可见肿瘤细胞c-myc产物的细胞质染色，3例可见细胞核染色。子宫内膜间质细胞始终呈阴性，3例可见肌层细胞核染色。在肿瘤内部，高分级且伴有深部肌层和血管浸润的肿瘤中常出现强染色，而伴有浅肌层浸润的高分化肿瘤中则常出现淡至中度染色。还普遍观察到肿瘤的肌层成分比位于子宫内膜的肿瘤染色更强的趋势。后者的染色分布常呈斑片状，而c-myc在肌层成分中的表达始终是均匀的。子宫内膜成分中的黏蛋白产生略多于肌层成分，但与c-myc表达或其他病理特征无关。本研究表明，c-myc在子宫内膜癌中呈可变表达，高c-myc表达可能与具有肌层和血管浸润能力的肿瘤细胞群体相关。
