Miyashita T, Hashimoto T, Gomez G, Townsend C M, Greeley G H, Thompson J C
Department of Surgery, University of Texas Medical Branch, Galveston 77555-0527.
Biol Signals. 1992 Sep-Oct;1(5):275-81. doi: 10.1159/000109332.
Release of neurotensin from the small intestine in response to administration of fat directly into the duodenum and ileum was examined in conscious dogs. The present results show that: (1) intraduodenal administration of fat causes a diphasic release of neurotensin which is mediated, at least in part, by cholinergic mechanisms, and (2) both a fatty acid (sodium oleate) and a triglyceride, when infused directly into an isolated ileal loop, stimulate a significant release of neurotensin. Our findings indicate that release of neurotensin is triggered by mechanisms originating in the proximal small intestine and by a direct contact of nutrients with the ileal mucosa.
在清醒的狗身上，研究了十二指肠和回肠直接注入脂肪后小肠中神经降压素的释放情况。目前的结果表明：（1）十二指肠内注入脂肪会导致神经降压素呈双相释放，这至少部分是由胆碱能机制介导的；（2）当脂肪酸（油酸钠）和甘油三酯直接注入离体回肠肠袢时，都会刺激神经降压素的显著释放。我们的研究结果表明，神经降压素的释放是由起源于近端小肠的机制以及营养物质与回肠黏膜的直接接触所触发的。
