Fujimura M, Khalil T, Sakamoto T, Greeley G H, Salter M G, Townsend C M, Thompson J C
Department of Surgery, University of Texas Medical Branch, Galveston.
Gastroenterology. 1989 Jun;96(6):1502-5. doi: 10.1016/0016-5085(89)90518-0.
Plasma neurotensin concentrations are rapidly elevated after oral ingestion or intraduodenal infusion of fat, apparently before fat reaches the ileum where neurotensin is highly concentrated. The purpose of this study was to investigate the site of neurotensin release and to determine whether neurotensin is released by direct luminal stimulation by fat in conscious dogs. Dogs were prepared with isolated jejunal or ileal segments and portal vein catheters. Release of neurotensin into the portal venous blood was examined by selective perfusion of each intestinal segment with sodium oleáte. The results of this study show that selective perfusion of the jejunum, but not the ileum, with sodium oleate, caused a significant release of neurotensin. We speculate that release of ileal neurotensin is not due to direct luminal stimulation, but is mediated by local neural or humoral intermediates.
口服或十二指肠内注入脂肪后，血浆神经降压素浓度会迅速升高，显然是在脂肪到达神经降压素高度浓缩的回肠之前。本研究的目的是调查神经降压素释放的部位，并确定神经降压素是否由清醒犬体内脂肪的直接管腔刺激释放。给犬制备孤立的空肠或回肠段以及门静脉导管。通过用油酸钠选择性灌注每个肠段来检查神经降压素向门静脉血中的释放情况。本研究结果表明，用油酸钠选择性灌注空肠而非回肠，会导致神经降压素显著释放。我们推测，回肠神经降压素的释放不是由于直接管腔刺激，而是由局部神经或体液介质介导的。
