Ohtani H, Uchiyama Y, Nishida A, Kano Y, Yamamoto S
Department of Clinical Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
Kitasato Arch Exp Med. 1992 Sep;65(2-3):123-30.
Two different types of monoclonal human immunoglobulins (M-components) with antistreptolysin-O (ASO) activity were investigated. The M-component FM with essential monoclonal gammopathy revealed to have an ASO activity, demonstrated not only by streptolysin-O neutralizing assay according to Ranz-Randall's method, but also by passive agglutination assays and precipitation on agar. The ASO activity was shown to reside in the Feb. These findings suggest that the M-component FM have a true antibody activity. On the other hand, ASO activity of M-component TT with multiple myeloma was detected only by streptolysin-O neutralizing assay, but the passive agglutinating assays and precipitation on agar showed no positive results. It has not been fully confirmed if the M-component TT behaves as a true antibody activity. Heterogeneity of the M-components with ASO activity was discussed.
对两种具有抗链球菌溶血素O（ASO）活性的不同类型的人单克隆免疫球蛋白（M成分）进行了研究。具有原发性单克隆丙种球蛋白病的M成分FM显示具有ASO活性，这不仅通过根据兰兹 - 兰德尔方法进行的链球菌溶血素O中和试验得到证实，还通过被动凝集试验和琼脂沉淀得到证实。ASO活性显示存在于Feb中。这些发现表明M成分FM具有真正的抗体活性。另一方面，患有多发性骨髓瘤的M成分TT的ASO活性仅通过链球菌溶血素O中和试验检测到，但被动凝集试验和琼脂沉淀均未显示阳性结果。M成分TT是否表现出真正的抗体活性尚未得到充分证实。讨论了具有ASO活性的M成分的异质性。
