Leyden J J, McGinley K J, Kligman A M
Arch Dermatol. 1976 Mar;112(3):333-8.
The role of microorganisms in dandruff was studied, by suppressing individually and then collectively the three major components of the scalp microflora. The effect on dandruff was assessed subjectively by clinical grading and objectively by the corneocyte count. No effect on dandruff was demonstrated when scalp organisms were suppressed. In the second group of experiments, dandruff was suppressed by selenium sulfide shampooling and the effect of continued suppression of Pityrosporum with topically applied amphotericin was measured. According to our criteria, dandruff returned to pretreatment levels, despite continued suppression of Pityrosporum. The studies demonstrate that the increased number of scalp microorganisms found in dandruff occurs as a secondary event to increased nutrients and that scalp organisms play no primary role in the pathogenesis of dandruff.
通过分别抑制以及随后集体抑制头皮微生物群的三大主要成分，对微生物在头皮屑形成中的作用进行了研究。通过临床分级主观评估对头皮屑的影响，并通过角质形成细胞计数客观评估。抑制头皮微生物时未显示出对头皮屑有影响。在第二组实验中，用硫化硒洗发抑制头皮屑，并测量局部应用两性霉素持续抑制马拉色菌的效果。根据我们的标准，尽管马拉色菌持续受到抑制，但头皮屑仍恢复到治疗前水平。这些研究表明，在头皮屑中发现的头皮微生物数量增加是营养物质增加的继发事件，并且头皮微生物在头皮屑的发病机制中不发挥主要作用。
