Laconi A, Buscemi M, Cardinale A, De Simone G F, Pasqualino A N, Tessitore V
Arch Sci Med (Torino). 1975 Apr-Jun;132(2):62-73.
The histochemical behaviour of alkaline phosphatase, adenosintriphosphatase, acid phosphatase and acetylglucosaminidase activities was studied in rat kidney treated with Chloromeridrin Hg. In these experimental conditions it was found that the nephrocytes in the proximal convoluted tubule present changes in the enzymatic activities examined, generally proportional to the doses employed. With lower doses of radionuclides, the histoenzymatic changes have a local character and are completely reversible after a month. With higher doses they take on a more extensive character and persis to some extent one month after treatment. These findings suggesti that Hg could be used clinically with due precautions.
研究了用氯汞丙脲处理的大鼠肾脏中碱性磷酸酶、三磷酸腺苷酶、酸性磷酸酶和乙酰氨基葡萄糖苷酶活性的组织化学行为。在这些实验条件下，发现近端曲管中的肾细胞在所检测的酶活性方面出现变化，通常与所用剂量成正比。使用较低剂量的放射性核素时，组织酶变化具有局部特征，一个月后完全可逆。使用较高剂量时，它们具有更广泛的特征，并且在治疗后一个月仍有一定程度的持续存在。这些发现表明，汞在采取适当预防措施的情况下可用于临床。
