Tessitore V, Cardinale A, Buscemi M, Gerbino A, Pasqualino A
Boll Soc Ital Biol Sper. 1979 Feb 15;55(3):219-23.
The histochemical behaviour of succinic dehydrogenase, isocitric dehydrogenase, acid phosphatase and acetylglucosaminidase activities was studied in rat liver treated with Au198-colloidal. In these experimental conditions it was found that the hepatocytes present changes in the enzymatic activities examined, generally proportional to the doses employed. With lower doses of radionuclides, the histoenzymatic changes have a local character and are completely reversible after a month. With higher doses they take on a more extensive character. These findings suggest that Au198 could be used clinically with due precautions.
研究了用胶体金198处理的大鼠肝脏中琥珀酸脱氢酶、异柠檬酸脱氢酶、酸性磷酸酶和乙酰氨基葡萄糖苷酶活性的组织化学行为。在这些实验条件下发现，肝细胞在所检测的酶活性方面出现变化，一般与所用剂量成比例。使用较低剂量的放射性核素时，组织酶变化具有局部特征，一个月后完全可逆。使用较高剂量时，变化更广泛。这些发现表明，在采取适当预防措施的情况下，金198可用于临床。
