Zwicker G M, Eyster R C, Sells D M, Gass J H
Marion Merrell Dow Inc., Indianapolis, Indiana 46268-0470.
Toxicol Pathol. 1992;20(4):576-84. doi: 10.1177/019262339202000404.
Primary malignant neoplasms of the brain and spinal cord occurred in 20/718 male (2.8%) and in 13/717 female (1.8%) Crl:CD Br strain Sprague-Dawley rats. Of 33 neoplasms, 30 were found in brain while 3 were in the spinal cord. In males and females, the most common brain neoplasm was astrocytoma (13 males, 9 females). Other neoplasms, granular cell tumor (1 male), mixed glioma (2 males, 1 female), reticulosis (1 male, 2 females), and oligodendroglioma (2 males), were especially uncommon. Spinal cord neoplasms included 2 schwannomas (1 male, 1 female) and an astrocytoma (1 male). The overall brain neoplasm incidence was similar for males (2.8%) compared to data compiled for this strain, and there was a 2-fold increase for females (1.8% vs 0.9%) compared to available incidence data.
在Crl:CD Br品系的斯普拉格-道利大鼠中，718只雄性大鼠中有20只（2.8%）发生原发性脑和脊髓恶性肿瘤，717只雌性大鼠中有13只（1.8%）发生原发性脑和脊髓恶性肿瘤。在33个肿瘤中，30个位于脑部，3个位于脊髓。在雄性和雌性大鼠中，最常见的脑肿瘤是星形细胞瘤（雄性13只，雌性9只）。其他肿瘤，颗粒细胞瘤（雄性1只）、混合性胶质瘤（雄性2只，雌性1只）、网状细胞增多症（雄性1只，雌性2只）和少突胶质细胞瘤（雄性2只），尤其罕见。脊髓肿瘤包括2例神经鞘瘤（雄性1只，雌性1只）和1例星形细胞瘤（雄性1只）。与该品系汇总数据相比，雄性大鼠的总体脑肿瘤发病率相似（2.8%），与现有发病率数据相比，雌性大鼠的发病率增加了两倍（1.8%对0.9%）。
