Janus K, Baranow-Baranowski S, Jakubowska D, Jankowiak D, Skrzypczak W F
Department of Animal Physiology, Faculty of Animal Husbandry, Agricultural University, Szczecin, Poland.
Arch Vet Pol. 1992;32(1-2):67-73.
In the experiment the values of parameters of antipyrine kinetics were defined (Vd - volume of distribution, t0.5 - half-life, CA - metabolic clearance) in calves in January, April, July and October 1986 and in January and July 1987. Statistically significant increase of distribution volume and increase of hepatic antipyrine clearance were recorded, as well as significant shortening of half-life of this substance in the organism of tested animals in summer 1986 and 1987, compared with the remaining seasons of the year. Antipyrine pharmacokinetics in winter, spring, autumn 1986 and winter 1986/87 did not differ significantly.
在该实验中，测定了1986年1月、4月、7月、10月以及1987年1月和7月犊牛体内安替比林动力学参数的值（Vd - 分布容积，t0.5 - 半衰期，CA - 代谢清除率）。结果显示，与一年中的其他季节相比，1986年和1987年夏季受试动物体内该物质的分布容积显著增加，肝脏对安替比林的清除率升高，且半衰期显著缩短。1986年冬、春、秋季以及1986/87年冬季的安替比林药代动力学无显著差异。
