Růzicka M, Stríbrná J, Englis M, Lánská V, Skibová J, Peregrin J
Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Cor Vasa. 1992;34(4):314-21.
Twenty-four hour urinary excretion of albumin (UEalb), IgG and beta-2 microglobulin was investigated at a 3 hour-interval in a control group (C) of healthy subjects, in 30 patients with renovascular hypertension (RVH), and in 16 patients with essential hypertension (EH). Mean UEalb in RVH was significantly higher than in C. A significant direct correlation was demonstrated between diastolic blood pressure and UEalb (p < 0.01). Microalbuminuria (MA) > or = 30 micrograms.min-1 was found in about 18% of RVH patients; it was higher than 16.7 micrograms.min-1 in approx. 31%. These results did not substantially differ from those obtained in patients with EH. The cause for increased UEalb in hypertensive patients may be functional, haemodynamic changes, or structural ones. In either case, MA indicates renal injury, and these patients should be given increased attention when monitoring their blood pressure and when selecting antihypertensive drugs.
在健康受试者对照组（C组）、30例肾血管性高血压（RVH）患者和16例原发性高血压（EH）患者中，每隔3小时对24小时尿白蛋白排泄量（UEalb）、IgG和β2微球蛋白进行检测。RVH组的平均UEalb显著高于C组。舒张压与UEalb之间存在显著的正相关（p<0.01）。约18%的RVH患者出现微量白蛋白尿（MA）≥30微克·分钟-1；约31%的患者MA高于16.7微克·分钟-1。这些结果与EH患者的结果无实质性差异。高血压患者UEalb增加的原因可能是功能性、血流动力学改变或结构性改变。无论哪种情况，MA都表明存在肾损伤，在监测这些患者的血压以及选择降压药物时，应给予更多关注。
