Freston J W, Forbes J A
J Clin Pharmacol. 1977 Jan;17(1):29-36. doi: 10.1002/j.1552-4604.1977.tb04583.x.
The effects of graded doses of anisotropine methylbromide on nocturanl gastric secretion were investigated in a double-blind crossover study in man. Single doses considerably higher than those usually employed for daytime use in adjunctive therapy of peptic ulcer disease significantly reduced acid secretion without significantly influencing heart rate, blood pressure, visual acuity, or visual accommodation. The duration of action of large doses was then evaluated in fasted and nonfasted subjects. A single dose reduced acid secretion for up to 8 hours, eliminating the nocturnal elevation of acid secretion characteristic of the normal circadian pattern. Near visual acuity and accommodation decreased, an effect more pronounced in fasted subjects, but the magnitude of visual impairment was small. These findings provide the basis for a controlled trial of high-dose nighttime therapy in peptic ulcer disease.
在一项针对人类的双盲交叉研究中，研究了不同剂量的甲溴东莨菪碱对夜间胃分泌的影响。单剂量显著高于通常用于消化性溃疡疾病辅助日间治疗的剂量，可显著减少胃酸分泌，而对心率、血压、视力或视觉调节无显著影响。然后在禁食和非禁食受试者中评估大剂量的作用持续时间。单剂量可减少胃酸分泌长达8小时，消除正常昼夜节律模式中夜间胃酸分泌升高的情况。近视力和调节能力下降，在禁食受试者中这种影响更明显，但视力损害程度较小。这些发现为消化性溃疡疾病高剂量夜间治疗的对照试验提供了依据。
