Bowers J H, Forbes J A, Freston J W
J Clin Pharmacol. 1978 Jul;18(7):365-71. doi: 10.1002/j.1552-4604.1978.tb01607.x.
Anisotropine methyl bromide, an anticholinergic, 80 mg given orally at 8 P.M., suppresses gastric acid secretion through the night without significant side effects. Thirty patients with endoscopy-proved symptomatic duodenal ulcer disease completed a randomized, double-blind, placebo-controlled trial of nighttime anisotropine methyl bromide therapy. Eleven (69 per cent) of 16 anisotropine methyl bromide-treated and six (43 per cent) of 14 placebo-treated subjects healed their ulcers within two weeks of starting treatment. The anisotropine methyl bromide-treated subjects averaged 0.63 +/- 0.27 (mean +/- S.E.) episodes of nocturnal pain during the treatment period versus 2.71 +/- 1.08 episodes in the placebo group (P = 0.06). This is the first reported study of this type designed to evaluate the efficacy of an anticholinergic agent in the healing of duodenal ulcers. Although not conclusive, the results suggest nighttime anisotropine methyl bromide therapy may be useful in the treatment of duodenal ulcer disease. Further studies seem warranted.
溴甲阿托品是一种抗胆碱能药物，晚上8点口服80毫克，可抑制夜间胃酸分泌，且无明显副作用。30例经内镜检查证实有症状的十二指肠溃疡患者完成了一项关于夜间溴甲阿托品治疗的随机、双盲、安慰剂对照试验。在开始治疗的两周内，16例接受溴甲阿托品治疗的患者中有11例（69%）溃疡愈合，14例接受安慰剂治疗的患者中有6例（43%）溃疡愈合。在治疗期间，接受溴甲阿托品治疗的患者夜间疼痛发作平均为0.63±0.27次（均值±标准误），而安慰剂组为2.71±1.08次（P = 0.06）。这是首次报道的旨在评估抗胆碱能药物对十二指肠溃疡愈合疗效的此类研究。尽管结果尚无定论，但提示夜间溴甲阿托品治疗可能对十二指肠溃疡疾病的治疗有用。似乎有必要进行进一步研究。
