Liassine N, Chelfi A, Rahal K
Laboratoire de bactériologie médicale, Institut Pasteur d'Algérie.
Arch Inst Pasteur Alger. 1992;58:85-94.
We report the isolation of 10 strains of enterobacteriaceae with a new quinolone's resistance. This resistance was detected by a diminution of inhibition's diameter around the disk of pefloxacin , and confirmed by the determination of Minimal Inhibiting Concentrations (M.I.C.). These strains, moreover multiresistant to multiple antibiotics, were isolated from patient's urines with repetitive urinary tract infections (paraplegics, lithiasic patients). None of this patients was treated by new quinolones. The incorrect use of old quinolones is probably responsible for the selection of this new quinolone's resistance.
我们报告分离出10株对新型喹诺酮耐药的肠杆菌科细菌。这种耐药性通过培氟沙星纸片周围抑菌圈直径的减小来检测，并通过最低抑菌浓度（M.I.C.）的测定得以确认。此外，这些菌株对多种抗生素多重耐药，是从患有复发性尿路感染的患者尿液中分离出来的（截瘫患者、结石患者）。这些患者均未接受新型喹诺酮类药物治疗。旧喹诺酮类药物的不当使用可能是导致这种新型喹诺酮耐药性产生的原因。
