Miller W R
Cancer Res. 1976 Feb;36(2 Pt 1):336-8.
The metabolism of both testosterone and dehydroepiandrosterone by 10 adenocarcinomas induced and grown in the presence of high prolactin (plasma prolactin greater than 220 ng/ml) was compared with the metabolism of 10 adenocarcinomas induced and grown in the presence of normal levels (plasma prolactin less than 60 ng/ml). The tumors associated with high prolactin significantly metabolized more testosterone to both 5alpha-dihydrotestosterone and 5alpha-androstanediol. The metabolism of dehydroepiandrosterone was similar in both groups of tumors. It is concluded that prolactin may differentially influence the metabolism of C19 steroids by rat mammary adenocarcinomas.
将在高催乳素（血浆催乳素大于220 ng/ml）存在下诱导并生长的10个腺癌中睾酮和脱氢表雄酮的代谢，与在正常水平（血浆催乳素小于60 ng/ml）存在下诱导并生长的10个腺癌的代谢进行比较。与高催乳素相关的肿瘤将更多的睾酮显著代谢为5α-双氢睾酮和5α-雄烷二醇。两组肿瘤中脱氢表雄酮的代谢相似。结论是催乳素可能对大鼠乳腺腺癌中C19类固醇的代谢产生不同影响。
