Mimouni V, Narce M, Poisson J P
Unité de Recherches de Nutrition Cellulaire et Métabolique, Université de Bourgogne, Faculté des Sciences Mirande, Dijon, France.
Biochim Biophys Acta. 1992 Jan 13;1133(2):187-92. doi: 10.1016/0167-4889(92)90068-m.
We studied hepatic microsomal gamma-linolenoyl-CoA elongation and fatty acid composition of liver microsomes in spontaneously diabetic Wistar BB rats. The liver microsomal gamma-linolenoyl-CoA elongation was decreased in diabetic Wistar BB rats during both normo- and hyperglycemic periods and restored during the hypoglycemic period following insulin treatment. These results are in agreement with our previously reported data on linoleic acid delta 6 and delta 5 desaturations and support the non-parallel relationship between the chain elongation system and the glycemia. The fatty acid composition of BB rat liver microsomes was only partially consistent with the gamma-linolenoyl-CoA elongation activity at the different periods of glycemia, probably because factors other than elongation impairments were involved in the evolution of fatty acid composition.
我们研究了自发性糖尿病Wistar BB大鼠肝脏微粒体中的γ-亚麻酰辅酶A延长反应以及肝脏微粒体的脂肪酸组成。在正常血糖期和高血糖期，糖尿病Wistar BB大鼠肝脏微粒体中的γ-亚麻酰辅酶A延长反应均降低，而在胰岛素治疗后的低血糖期则恢复。这些结果与我们之前报道的关于亚油酸Δ6和Δ5去饱和反应的数据一致，并支持链延长系统与血糖之间的非平行关系。在血糖的不同时期，BB大鼠肝脏微粒体的脂肪酸组成仅部分与γ-亚麻酰辅酶A延长活性一致，这可能是因为除了延长障碍之外的其他因素也参与了脂肪酸组成的演变。
