Mimouni V, Poisson J P
Laboratoire de Physiologie Animale et de la Nutrition, Faculté des Sciences Mirande, Dijon, France.
Horm Metab Res. 1990 Aug;22(8):405-7. doi: 10.1055/s-2007-1004934.
We studied linoleic acid delta 5 and dihomo-gamma-linolenic acid delta 5 desaturations, and fatty acid composition, of liver microsomes in the insulin-dependent spontaneously diabetic adult female BB rat. These desaturations were defective along the normo- and hyper-glycemic period and restored during the hypoglycemic period which followed the insulin injection to the diabetic rats. The fatty acid composition of BB rats microsomes was not consistent with the desaturase activities at the different periods of glycemia, probably because other factors than desaturation impairments were involved in the evolution of fatty acid composition.
我们研究了胰岛素依赖型成年自发糖尿病雌性BB大鼠肝脏微粒体中Δ5-亚油酸和Δ5-二高-γ-亚麻酸去饱和作用以及脂肪酸组成。在正常血糖期和高血糖期，这些去饱和作用存在缺陷，而在给糖尿病大鼠注射胰岛素后的低血糖期恢复。BB大鼠微粒体的脂肪酸组成在不同血糖期与去饱和酶活性不一致，这可能是因为脂肪酸组成的变化涉及除去饱和损伤之外的其他因素。
