Chandrasekhar Y, Heiner J, Osuamkpe C, Nagamani M
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston 77550.
Am J Obstet Gynecol. 1992 Jan;166(1 Pt 1):64-9. doi: 10.1016/0002-9378(92)91831-t.
The purpose of this study is to determine if the human myometrium has receptors for insulin-like growth factors I and II and whether the concentration of these receptors is increased in leiomyomas.
Specific binding of iodine 125-labeled insulin-like growth factor I and II was examined in the membrane preparations of myometrium and leiomyomas obtained from 10 women with uterine leiomyomas.
Binding studies indicate presence of specific binding sites for both insulin-like growth factors I and II in the myometrium and leiomyoma. The concentration of binding sites for insulin-like growth factor I, but not for insulin-like growth factor II, was significantly (p less than 0.01) higher in leiomyomas than in the myometrium. The dissociation constants for insulin-like growth factors I and II receptors in both myometrium and leiomyoma were similar.
insulin-like growth factor I, but not insulin-like growth factor II, receptors are increased in leiomyomas compared with those in myometrium, indicating that insulin-like growth factor I may play a role in the generation and/or growth of this tumor.
本研究旨在确定人类子宫肌层是否存在胰岛素样生长因子I和II的受体，以及这些受体的浓度在平滑肌瘤中是否升高。
检测了从10例子宫平滑肌瘤患者获取的子宫肌层和平滑肌瘤膜制剂中125碘标记的胰岛素样生长因子I和II的特异性结合情况。
结合研究表明，子宫肌层和平滑肌瘤中均存在胰岛素样生长因子I和II的特异性结合位点。平滑肌瘤中胰岛素样生长因子I的结合位点浓度显著高于子宫肌层（p<0.01），而胰岛素样生长因子II的结合位点浓度则无显著差异。子宫肌层和平滑肌瘤中胰岛素样生长因子I和II受体的解离常数相似。
与子宫肌层相比，平滑肌瘤中胰岛素样生长因子I的受体增加，而胰岛素样生长因子II的受体无增加，这表明胰岛素样生长因子I可能在该肿瘤的发生和/或生长中起作用。
