Nagamani M, Stuart C A
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston 77550.
Fertil Steril. 1992 Jul;58(1):120-3. doi: 10.1016/s0015-0282(16)55147-4.
To investigate whether there are increased binding sites for insulin in the leiomyomas of the uterus.
Samples of myomas and myometrium were obtained from seven patients with myomas at the time of hysterectomy. Binding studies were performed with [125I] insulin.
The percent total binding of [125I] insulin in the myomal tissues (mean +/- SE 20.7% +/- 2.3%/100 micrograms protein) was significantly higher (P less than 0.01) than that in the myometrium (14.7% +/- 1.3%/100 micrograms protein). Scatchard analysis revealed that the increase in binding is because of increase in receptor affinity.
There is increased binding of insulin in the myomas because of increase in receptor affinity. This could increase the sensitivity of the biological response of the myomal cells to insulin.
研究子宫平滑肌瘤中胰岛素结合位点是否增加。
在子宫切除术时，从7例子宫肌瘤患者获取肌瘤和子宫肌层样本。用[125I]胰岛素进行结合研究。
肌瘤组织中[125I]胰岛素的总结合百分比（平均±标准误20.7%±2.3%/100微克蛋白质）显著高于子宫肌层（14.7%±1.3%/100微克蛋白质）（P<0.01）。Scatchard分析显示结合增加是由于受体亲和力增加。
由于受体亲和力增加，肌瘤中胰岛素结合增加。这可能会增加肌瘤细胞对胰岛素生物反应的敏感性。
