Gomez-Sanchez E P, Fort C, Thwaites D
Research Division, James A. Haley Veterans Hospital, Tampa, Florida.
Am J Physiol. 1992 Jan;262(1 Pt 1):E96-9. doi: 10.1152/ajpendo.1992.262.1.E96.
The development of hypertension in the S/JR rat is accelerated and exacerbated by a high salt consumption. It has been reported that the intracerebroventricular infusion of RU28318, a selective mineralocorticoid antagonist, at doses that are ineffective when administered subcutaneously, inhibits the development of the hypertension produced by the subcutaneous infusion of aldosterone or deoxycorticosterone in normotensive rats. RU28318 was continuously infused intracerebroventricularly or subcutaneously in Dahl S/JR rats before or after the onset of hypertension induced by a high-salt diet. The centrally infused mineralocorticoid antagonist inhibited the initiation of the increase in blood pressure, when the infusion was started concomitantly with the high-salt diet, and blocked its further increase in rats whose blood pressure had already become significantly elevated with 2 wk of a high-salt diet. The subcutaneously infused mineralocorticoid antagonist had no effect. These data serve to strengthen the hypothesis that the mineralocorticoid receptor in the brain is crucial to the genesis of certain forms of hypertension.
高盐摄入会加速并加剧S/JR大鼠高血压的发展。据报道，在皮下给药无效的剂量下，脑室内注入选择性盐皮质激素拮抗剂RU28318，可抑制正常血压大鼠皮下注入醛固酮或脱氧皮质酮所产生的高血压的发展。在高盐饮食诱导的高血压发作之前或之后，将RU28318持续脑室内或皮下注入Dahl S/JR大鼠。当与高盐饮食同时开始注入时，中枢注入的盐皮质激素拮抗剂可抑制血压升高的起始，并阻止血压在已经通过2周高盐饮食显著升高的大鼠中进一步升高。皮下注入的盐皮质激素拮抗剂则没有效果。这些数据有助于强化这样一种假说，即大脑中的盐皮质激素受体对某些形式高血压的发生至关重要。
