Charles M A, Imagawa W, Forsham P H, Grodsky G M
Endocrinology. 1976 Mar;98(3):738-42. doi: 10.1210/endo-98-3-738.
Islet isografts were injected into the portal veins of rats made diabetic with streptozotocin. The isografts normalized not only plasma glucose and insulin levels but also the elevated plasma immunoreactive glucagon level. The in vitro basal insulin secretion and prompt sensitivity to glucose were shown directly by perfusing isolated livers containing transplanted islets. In vitro glucagon secretion to an arginine stimulus could not be demonstrated, although it would have been expected demonstrated, although it would have been expected in normal islets. Thus, it appears that insulin derived from transplanted islets is capable of correcting endogenous hyperglucagonemia and of ameliorating the effects of experimental diabetes while transplanted islet glucagon secretion is relatively suppressed.
将胰岛同基因移植到用链脲佐菌素诱导糖尿病的大鼠门静脉中。这些同基因移植不仅使血浆葡萄糖和胰岛素水平恢复正常，还使升高的血浆免疫反应性胰高血糖素水平恢复正常。通过灌注含有移植胰岛的离体肝脏，直接显示了体外基础胰岛素分泌以及对葡萄糖的即时敏感性。尽管在正常胰岛中预期会出现，但体外对精氨酸刺激的胰高血糖素分泌却未得到证实。因此，似乎移植胰岛来源的胰岛素能够纠正内源性高胰高血糖素血症并改善实验性糖尿病的影响，而移植胰岛的胰高血糖素分泌则受到相对抑制。
