Arii S, Tanaka J, Yamazoe Y, Minematsu S, Morino T, Fujita K, Maetani S, Tobe T
First Department of Surgery, Kyoto University Faculty of Medicine, Japan.
Cancer. 1992 Feb 15;69(4):913-9. doi: 10.1002/1097-0142(19920215)69:4<913::aid-cncr2820690413>3.0.co;2-t.
To establish useful predictors of the intrahepatic recurrence of hepatocellular carcinoma (HCC) after partial hepatectomy, retrospective analyses of clinical and pathologic factors were done in 112 of 206 patients treated by partial hepatectomy. The absence or presence of intrahepatic recurrence was confirmed by a follow-up study. Cancer-free survival rates after 1, 2, 3, and 5 years were 54.8%, 36.7%, 32.5%, and 25.6%, respectively. The significant factors affecting recurrence were tumor size, number of tumors, cancer cell infiltration of the fibrous capsule of the tumor, portal involvement, and stage of the tumor, but the grade of anaplasia according to Edmondson-Steiner's classification and the severity of associated liver cirrhosis did not show a correlation with the incidence of recurrence. According to Akaike's Information Criteria (AIC), tumor number is useful for predicting early prognosis, and capsular infiltration is a good indicator of long-term survival. However, portal involvement gives much prognostic information throughout the entire postoperative period.
为了建立肝细胞癌（HCC）肝部分切除术后肝内复发的有效预测指标，我们对206例行肝部分切除术患者中的112例进行了临床和病理因素的回顾性分析。通过随访研究确认肝内复发的有无。1年、2年、3年和5年的无癌生存率分别为54.8%、36.7%、32.5%和25.6%。影响复发的显著因素包括肿瘤大小、肿瘤数量、肿瘤纤维包膜的癌细胞浸润、门静脉受累情况和肿瘤分期，但根据Edmondson-Steiner分类法的间变程度以及相关肝硬化的严重程度与复发率无相关性。根据赤池信息准则（AIC），肿瘤数量有助于预测早期预后，包膜浸润是长期生存的良好指标。然而，门静脉受累在整个术后期间提供了很多预后信息。
